| Saturday, September 15 | |||||
| TIME (ET) | MATCHUP | TV | PPV | ||
| 12:00 PM | Wake Forest at No. 5 Florida State |    |
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| 12:00 PM | California at No. 12 Ohio State |  |
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| 12:00 PM | No. 13 Virginia Tech at Pittsburgh |  |
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| 12:00 PM | No. 16 TCU at Kansas | FX | |||
| 12:00 PM | Western Michigan at Minnesota | Big Ten Network | |||
| 12:00 PM | Arkansas State at Nebraska |  |
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| 12:00 PM | Louisiana-Lafayette at Oklahoma State | ||||
| 12:00 PM | Northern Illinois at Army | CBS Sports Network | |||
| 12:00 PM | Charleston Southern at Illinois | Big Ten Network | |||
| 12:00 PM | Bethune-Cookman at Miami (FL) |  |
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| 12:00 PM | Eastern Michigan at Purdue | Big Ten Network | |||
| 12:21 PM | Louisiana-Monroe at Auburn | SEC Network |
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| 12:30 PM | Connecticut at Maryland | |
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| 12:30 PM | Presbyterian at Vanderbilt | |
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| 3:00 PM | Tennessee Tech at No. 4 Oregon | Pac-12 Network | |||
| 3:00 PM | Furman at No. 11 Clemson | |
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| 3:30 PM | No. 1 Alabama at Arkansas | CBS | |||
| 3:30 PM | Massachusetts at No. 17 Michigan | Big Ten Network | |||
| 3:30 PM | North Carolina at No. 19 LouisvilleCoverage map » | |
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| 3:30 PM | Virginia at Georgia Tech | |
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| 3:30 PM | Boston College at Northwestern | Big Ten Network | |||
| 3:30 PM | Navy at Penn StateCoverage map » | |
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| 3:30 PM | Morgan State at Akron | |
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| 3:30 PM | Northern Iowa at Iowa | Big Ten Network | |||
| 3:30 PM | Texas A&M at Southern Methodist | ||||
| 3:30 PM | East Carolina at Southern Miss | CBS Sports Network | |||
| 4:00 PM | Miami (OH) at Boise State | NBC Sports Network | |||
| 4:00 PM | Stony Brook at Syracuse | |
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| 4:00 PM | Portland State at Washington | FX | |||
| 4:00 PM | Florida International at UCF | ||||
| 4:30 PM | James Madison vs. No. 9 West Virginia* | ||||
| 6:00 PM | No. 18 Florida at No. 23 Tennessee | |
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| 6:00 PM | South Alabama at North Carolina State | |
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| 6:00 PM | UTSA at Georgia State | ||||
| 6:00 PM | Cal Poly at Wyoming | ||||
| 6:30 PM | Ohio at Marshall | ||||
| 7:00 PM | UAB at No. 8 South Carolina | |
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| 7:00 PM | North Texas at No. 15 Kansas State | ||||
| 7:00 PM | Western Kentucky at Kentucky | |
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| 7:00 PM | Arizona State at Missouri | |
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| 7:00 PM | North Carolina Central at Duke | |
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| 7:00 PM | Nicholls State at Tulsa | ||||
| 7:00 PM | Middle Tennessee at Memphis | ||||
| 7:00 PM | Delaware State at Cincinnati | |
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| 7:00 PM | Rice at Louisiana Tech | |
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| 7:00 PM | New Mexico at Texas Tech | ||||
| 7:00 PM | Bowling Green at Toledo | |
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| 7:00 PM | Mississippi State at Troy | |
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| 7:05 PM | Sam Houston State at Baylor | ||||
| 7:05 PM | Northwestern State at Nevada | ||||
| 7:30 PM | No. 2 USC at No. 21 Stanford | FOX | |||
| 7:30 PM | Florida Atlantic at No. 7 Georgia | |
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| 8:00 PM | Idaho at No. 3 LSU | |
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| 8:00 PM | No. 20 Notre Dame at No. 10 Michigan State | |
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| 8:00 PM | North Dakota at San Diego State | ||||
| 8:00 PM | Colorado State at San Jose State | |
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| 8:00 PM | Western Illinois at Iowa State | ||||
| 8:00 PM | Ball State at Indiana | Big Ten Network | |||
| 8:00 PM | Utah State at Wisconsin | Big Ten Network | |||
| 8:00 PM | Colorado at Fresno State | CBS Sports Network | |||
| 8:00 PM | New Mexico State at UTEP | ||||
| 9:15 PM | No. 14 Texas at Ole Miss | |
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| 10:00 PM | No. 25 Brigham Young at Utah | |
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| 10:30 PM | Houston at No. 22 UCLA | ||||
| 10:30 PM | South Carolina State at No. 24 Arizona | ||||
| Sunday, September 16 | |||||
| TIME (ET) | MATCHUP | TV | PPV | ||
| 12:00 AM | Lamar at Hawaii | ||||
* – game played at a neutral location