| SUN, SEP 16 | TIME (EST) | TV | LOCATION | |
| Kansas City at Buffalo | 1:00 PM | CBS | Ralph Wilson Stadium | |
| Cleveland at Cincinnati | 1:00 PM | CBS | Paul Brown Stadium | |
| Minnesota at Indianapolis | 1:00 PM | FOX | Lucas Oil Stadium | |
| New Orleans at Carolina | 1:00 PM | FOX | Bank of America Stadium | |
| Houston at Jacksonville | 1:00 PM | CBS | EverBank Field | |
| Oakland at Miami | 1:00 PM | CBS | Sun Life Stadium | |
| Arizona at New England | 1:00 PM | FOX | Gillette Stadium | |
| Tampa Bay at NY Giants | 1:00 PM | FOX | MetLife Stadium | |
| Baltimore at Philadelphia | 1:00 PM | CBS | Lincoln Financial Field | |
| Washington at St. Louis | 4:05 PM | FOX | Edward Jones Dome | |
| Dallas at Seattle | 4:05 PM | FOX | CenturyLink Field | |
| NY Jets at Pittsburgh | 4:25 PM | CBS | Heinz Field | |
| Tennessee at San Diego | 4:25 PM | CBS | Qualcomm Stadium | |
| Detroit at San Francisco | 8:20 PM | NBC | Candlestick Park |