| TIME (ET) | TV | LOCATION | ||
| St. Louis at Chicago | 1:00 PM | FOX | Soldier Field | |
| Buffalo at Cleveland | 1:00 PM | CBS | Cleveland Browns Stadium | |
| Tampa Bay at Dallas | 1:00 PM | FOX | Cowboys Stadium | |
| NY Jets at Miami | 1:00 PM | CBS | Sun Life Stadium | |
| San Francisco at Minnesota | 1:00 PM | FOX | Mall of America Field | |
| Kansas City at New Orleans | 1:00 PM | CBS | Mercedes-Benz Superdome | |
| Cincinnati at Washington | 1:00 PM | CBS | FedEx Field | |
| Detroit at Tennessee | 1:00 PM | FOX | LP Field | |
| Jacksonville at Indianapolis | 1:00 PM | CBS | Lucas Oil Stadium | |
| Philadelphia at Arizona | 4:05 PM | FOX | U of Phoenix Stadium | |
| Atlanta at San Diego | 4:05 PM | FOX | Qualcomm Stadium | |
| Houston at Denver | 4:25 PM | CBS | Sports Authority Field at Mile High | |
| Pittsburgh at Oakland | 4:25 PM | CBS | Oakland-Alameda County Coliseum | |
| New England at Baltimore | 8:20 PM | NBC | M&T Bank Stadium |